第一次治疗PKU.
KUVAN® (sapropterin盐酸盐) Tablets and Powder for Oral Solution is the first 十大赌博靠谱网络平台-approved medication for phenylketonuria (PKU). KUVAN is a form of BH4, the cofactor of the PAH enzyme, which helps the enzyme break down Phe. KUVAN将与限制高磷饮食一起使用.
Learn more about 十大赌博平台排行榜’s 15-year commitment to PKU with the short film “The Pursuit of PKU.”
什么是KUVAN?
KUVAN® (sapropterin盐酸盐) Tablets for Oral Use and Powder for Oral Solution are prescription medicines used to lower blood Phe levels in adults and children over one month of age with a certain type of phenylketonuria (PKU). KUVAN应与限制高磷饮食一起使用.
重要安全资讯
关于KUVAN，我应该知道的最重要的信息是什么? KUVAN会导致严重的副作用，包括:
- 严重的过敏反应，包括过敏反应. Stop taking KUVAN and get medical help right away if you develop any of these signs or symptoms of a severe allergic reaction:
- 喘息、咳嗽或呼吸困难
- 感觉脸红、恶心、头晕或晕眩
- Rash
- Inflammation of the lining of the esophagus or stomach (esophagitis and gastritis). Your doctor will monitor you for symptoms of inflammation in your upper gastrointestinal tract, 包括胃和食道. If untreated that inflammation can lead to serious side effects including narrowing of the esophagus, ulcers, and bleeding. Call your doctor right away if you have any of these signs or symptoms:
- 上腹部(胃区)、食道或喉咙疼痛
- 恶心、吞咽困难、食欲不振或呕吐
- 呕吐物或粪便中有血
- 黑色的柏油大便
- Phe水平过低. 患者在KUVAN治疗期间出现低血Phe. Low blood Phe is more common in children under the age of 7 who take high doses of KUVAN each day.
- 过多或持续的活动(多动)可能发生在KUVAN. 如果你有任何多动症的迹象，告诉你的医生，包括:
- 坐立不安或四处走动
- 话太多
在服用KUVAN之前我应该告诉我的医生什么? Before you take KUVAN, tell your doctor about all your medical conditions, including if you:
- Are allergic to sapropterin dihydrochloride or any of the ingredients in KUVAN
- 营养不良或食欲不振
- 是否怀孕或计划怀孕
- 是母乳喂养还是计划母乳喂养. 目前尚不清楚KUVAN是否会进入母乳. Talk to your doctor about the best way to feed your baby if you take KUVAN.
告诉你的医生你服用的所有药物， including prescription and over-the-counter medicines, vitamins, and herbal and dietary supplements. KUVAN和其他药物可能相互作用. 特别是告诉你的医生，如果你服用:
- 左旋多巴一种含有左旋多巴的药物
- An antifolate medicine such as methotrexate, valproic acid, phenobarbital, trimethoprim
- Sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), vardenafil (Staxyn, Levitra)
Tell your doctor if you are not sure if your medicine is one that is listed above. 了解你服用的药物. Keep a list of them to show your doctor and pharmacist when you get a new medicine.
我应该怎样服用KUVAN?
See the detailed “Instructions for Use” that comes with KUVAN for information about the correct way to dissolve and take a dose of KUVAN tablets or KUVAN powder for oral solution.
- KUVAN并不适用于所有人. It is not possible to know if KUVAN will work for you until you start taking KUVAN. Your doctor will check your blood Phe levels when you start taking KUVAN to see if the medicine is working.
- 完全按照医生的建议服用KUVAN
- You can swallow KUVAN tablets whole or dissolve the tablets in water or apple juice
- KUVAN powder for oral solution should be dissolved in water or apple juice
- KUVAN应与特定的pku饮食一起服用. 你对饮食的任何改变都可能影响你的血液Phe水平. Follow your doctor’s instructions carefully and do not make any changes to your dietary Phe intake without first talking with your doctor. 即使你用KUVAN, 如果你的Phe水平控制得不好, 你可能会出现严重的神经问题.
- Your doctor should continue to monitor your blood Phe levels often during your treatment with KUVAN to make sure that your blood Phe levels are not too high or too low and frequent monitoring for pediatric patients is recommended. 高Phe和低Phe都会导致严重的问题. Active management of dietary Phe intake while taking KUVAN is required.
- If you have a fever, or if you are sick, your blood Phe level may go up. Tell your doctor as soon as possible so he or she can change your dose of KUVAN to help keep your blood Phe levels in the desired range.
- If you forget to take your dose of KUVAN, take it as soon as you remember that day. 不要一天服两剂.
- 如果你服用了太多的KUVAN，请打电话给你的医生寻求建议
KUVAN最常见的副作用是: headache, runny nose and nasal congestion, sore throat, diarrhea, vomiting, and cough.
这些并不是KUVAN所有可能的副作用. 欲了解更多信息，请咨询您的医生或药剂师. 打电话给你的医生咨询有关副作用的医疗建议.
你可以拨打1-800-十大赌博靠谱网络平台-1088向十大赌博靠谱网络平台报告副作用 www.fda.gov/medwatch. 您也可以拨打1-866-906-6100向十大赌博平台排行榜报告副作用.
请点击阅读完整的处方信息 here.
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